Thanks for giving it a go! So, what I wanted to do was display my attachments in a masonry layout, with an infinite scroll…if you go to http://www.joshrodg.com/test/inductees you can see my working version. I found a script that showed how to integrate both masonry and isotope layouts into WordPress. I still need to tweak some things, but the functionality is there. I use normal WordPress pagination and chose to show 12 posts, before it loads more.
I am curious to see what kind of issues you ran into…maybe I can share the code I am using.